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One Voice in the Cosmic Fugue II

July 25, 2010

Following on from my previous quote from Cosmos, here is another quote. This one is talking about the paradox of the complexity and simplicity of a cell:

If we plunged through a pore into the nucleus of the cell, we would find something that resembles an explosion in a spaghetti factory — a disorderly multitude of coils and strands, which are the two kinds of nucleic acids: DNA, which knows what to do, and RNA, which conveys the instructions issued by DNA to the rest of the cell. These are the best that four billion years of evolution could produce, containing the full complement of information on how to make a cell, a tree or a human work. The amount of information in human DNA, if written out in ordinary language, would occupy a hundred thick volumes. What is more, the DNA molecules know how to make, with only very rare exceptions, identical copies of themselves. They know extraordinarily much.

Yet again, the final sentence strikes me as a wonderful turn of phrase, particularly as I read everything Carl wrote with the memory of his voice and its peculiar tempo playing in my head.

The Human Genome Project was only half-way through mapping the human DNA when Carl died in 1996. The Project ran from 1990-2003 and, just as we once did with hieroglyphics, we are still only just tapping the surface in deciphering what it means nearly ten years later (also see the extensive Wikipedia entry). Since this initial, mammoth breakthrough, many more donor genomes have been sequenced — it seems to be a growing industry.

And as for Carl’s estimate of the size it would take in print form, the original genome has subsequently been printed into 119 bound volumes, containing all of the three billion base pairs. Though I imagine it would make rubbish bedtime reading…

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